yes, essentially the entire parade route will be off limits to cars and pedestrians.
I don't know the parade route specifically, but it seems to me that it's going to be something like this:
You can be virtually assured that you will have trouble getting in and out of places from about Saturday noon to Sunday in the late afternoon.
The rest of the city will be snarled with vicious, impenetrable traffic at the same time due to the closures.
You would be wise to just stay at home, or go far away from the areas that are likely to be closed.
Here's what we've gathered so far, in a map -- red means road closures, yellow is affected area business closures
(click for a larger version)
